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Breast Cancer Subtypes: Clinicopathologic Features and Treatment Considerations
Adrienne N Cobb1,2, Rebecaa Czaja3, Julie Jorns3
1Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226, USA.
Current Breast Cancer Reports
|June 27, 2025
Summary
This review details ten breast cancer subtypes, highlighting how their unique histology impacts patient survival. Some subtypes show favorable outcomes, while others indicate a more aggressive disease course requiring further research for targeted treatments.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Breast cancer comprises diverse subtypes with varying clinical behaviors.
- Histological differences significantly influence tumor biology, prognosis, and treatment response.
Purpose of the Study:
- To review ten distinct breast cancer subtypes.
- To outline their clinicopathologic features and treatment implications.
Main Methods:
- Literature review of unique breast cancer subtypes.
- Analysis of clinicopathologic features and survival data.
Main Results:
- Mucinous, papillary, tubular, and apocrine subtypes exhibit favorable biology and better survival rates compared to invasive ductal carcinoma.
- Metaplastic and adenoid cystic subtypes are more aggressive, associated with poorer patient prognosis.
Conclusions:
- Breast cancer subtypes possess distinct biological and prognostic profiles.
- Rarity of certain subtypes necessitates further research to establish definitive treatment protocols.
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