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Updated: Sep 17, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts

Published on: February 24, 2015

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Facile and Practical Synthesis of Substituted Piperidine-2,6-Diones Under Transition-Metal Free Condition

Yue-Hua Liu1, Zhang-Qin Xue1, Kai-Wen Yang1

  • 1School of Pharmaceutical Sciences and Institute of Materia Medical, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission (Shandong Academy of Medical Sciences), Key Lab for Rare and Uncommon Diseases of Shandong Province, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.

Chemistryopen
|June 27, 2025
PubMed
Abstract

Keywords:
Basic promoterFacile and practical synthesisMichael addition/intramolecular imidation cascadePiperidine-2,6-dione scaffoldTransition-metal free

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