Detecting congenital chiasmal misrouting using multichannel VEPs: protocol for a scoping review

Area of Science:

• Neuroscience
• Ophthalmology
• Clinical Electrophysiology

Background:

• Multi-channel visual evoked potentials (mcVEPs) offer objective evaluation of chiasmal misrouting.
• Chiasmal misrouting involves crossed asymmetry in cortical responses, often seen in albinism.
• Variability in mcVEP application and analysis necessitates a review of current practices.

Purpose of the Study:

• To understand the application of mcVEPs in investigating congenital chiasmal misrouting.
• To identify outcomes measured, interpreted, and reported in mcVEP studies of chiasmal misrouting.
• To explore variations in mcVEP methodology and reporting across different centers.

Main Methods:

• Prospective scoping review protocol.
• Inclusion of peer-reviewed and grey literature on mcVEP for non-acquired chiasmal misrouting.
• Systematic literature searches across major databases (MEDLINE, Embase, Cochrane, Web of Science).

Main Results:

• Data extraction will focus on mcVEP methodology, study design, and reported outcomes.
• Results will be synthesized and mapped to provide a comprehensive overview.
• The review will identify areas for potential adaptation, optimization, or guideline development.

Conclusions:

• This review protocol will provide a structured approach to understanding mcVEP use in congenital chiasmal misrouting.
• It aims to consolidate current knowledge and highlight gaps in methodology and reporting.
• Findings will inform future research and clinical practice standardization.