Related Experiment Video

Updated: Sep 17, 2025

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

22.0K

Thrombolytic Therapy in Prepubescent Pediatric Frostbite Patients

Melanie McCormick1,2, Nicholas Larson1, Rob Newsom3

  • 1Regions Hospital Burn Center, St. Paul, MN 55101, United States.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|June 28, 2025
PubMed

Insights

Severe frostbite in children is rare. Thrombolytic therapy showed excellent tissue preservation and no adverse effects in a pediatric case series, suggesting its potential for treating frostbite in children.

Area of Science:

  • Pediatric Medicine
  • Trauma Surgery
  • Emergency Medicine

Background:

  • Frostbite injury in prepubescent children is uncommon.
  • Limited research and specific management guidelines exist for pediatric frostbite.
  • Severe frostbite requires prompt and effective treatment to prevent tissue loss.

Purpose of the Study:

  • To evaluate the efficacy and safety of thrombolytic therapy in prepubescent children with severe frostbite.
  • To present a case series of pediatric patients treated with thrombolytics for frostbite.
  • To explore the potential of thrombolytic therapy in improving outcomes for pediatric frostbite cases.

Main Methods:

  • A case series of five prepubescent pediatric patients with severe frostbite was reviewed.
  • Patients were treated with thrombolytic agents at an American Burn Association (ABA) verified burn center.
  • Outcomes, including tissue preservation and adverse effects, were documented.

Main Results:

  • All five patients experienced excellent preservation of affected tissues.
  • No adverse events were reported in relation to thrombolytic administration.
  • The treatment demonstrated a positive impact on preventing tissue damage.

Conclusions:

  • Thrombolytic therapy shows promise as an effective treatment for severe frostbite in prepubescent children.
  • This case series supports the consideration of thrombolytics for pediatric frostbite management.
  • Further research is necessary to establish standardized treatment protocols for pediatric frostbite.

Keywords:
frostbitepediatricthrombolytic therapy

More Related Videos

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

2.9K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
27
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
47
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.9K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
921