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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
The Role of Sunscreen in Protection from Melanoma
Karin Roszell1, Tasneem F Mohammad1
1Department of Dermatology, Henry Ford Health, 3031 West Grand Boulevard, Detroit, MI 48202, USA.
None:
Melanoma is one of the leading causes of skin cancer deaths and is driven by ultraviolet (UV) radiation and subsequent DNA damage. Although studies on sunscreen's effectiveness in preventing melanoma are inconsistent and limited, the available high-quality data suggest that sunscreen use can reduce melanoma incidence. Challenges include increased sun exposure with sunscreen use, poor sunscreen application, and limited UVA protection of sunscreens. Current guidelines recommend broad-spectrum sunscreens with sun protection factor greater than 30, regular reapplication, and additional sun-protective measures. Ongoing research is essential to better understand melanoma and refine prevention strategies.
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