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Long-Term Cardio-Renal-Metabolic Complications Following Pre-eclampsia

Bianca Davidson1, Brain Rayner1, Nicola Wearne1

  • 1Division of Hypertension and Nephrology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Cardiology Clinics
|June 29, 2025
PubMed

Insights

Hypertensive disorders of pregnancy, like pre-eclampsia, pose long-term health risks for mothers and children. Research is exploring causes, variations, and improved management strategies for better outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Public Health

Background:

  • Hypertensive disorders of pregnancy affect ~10% of pregnancies, with rising prevalence.
  • These conditions increase long-term chronic disease risk for mothers.
  • In utero exposure to pre-eclampsia has emerging evidence of long-term adverse effects on children.

Purpose of the Study:

  • To explore current theories on the pathogenesis of long-term consequences.
  • To examine regional variations in long-term outcomes.
  • To review current management and screening strategies and identify future research needs.

Main Methods:

  • Literature review of recent theories on pathogenesis.
  • Analysis of available data on regional variations in long-term consequences.
  • Review of current clinical management and screening protocols.

Main Results:

  • Discusses emerging evidence on long-term maternal and child health risks.
  • Highlights the need for further research into pathogenesis and regional differences.
  • Identifies gaps in current management and screening strategies.

Conclusions:

  • Hypertensive disorders of pregnancy have significant, lasting impacts on maternal and child health.
  • Further research is crucial for understanding long-term consequences and improving care.
  • Enhanced management and screening are needed to mitigate long-term risks.

Keywords:
Cardiovascular diseaseChronic kidney diseaseDiabetesLong-term diseaseOffspringPre-eclampsia

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