Manganese-chelated liposomes encapsulating antiepileptic drug molecules for epilepsy treatment

Epilepsy is characterized by unpredictable and recurrent seizures, necessitating long-term prophylactic medication to maintain high drug concentrations at the site of onset. However, this approach, coupled with the blood-brain barrier (BBB)'s impediment, often leads to significant toxicity and drug resistance. We report a novel liposomal drug delivery system for epilepsy treatment: liposomes encapsulating two first-line clinical drugs chelated by metal ions. This liposomal formulation demonstrates high biosafety both in vitro and in vivo. Through in vivo fluorescence imaging and T1-weighted magnetic resonance imaging (MRI), we verified its efficient penetration into the blood-brain barrier and effective accumulation at epileptic foci. This targeted delivery prevented substantial brain tissue damage caused by epilepsy and maintained neurons in the normal physiological state. Our work presents a promising new therapeutic option for the clinical management of epilepsy.