Related Experiment Video
Updated: Sep 17, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
HIV Is Associated With Subclinical Coronary Atherosclerosis: A Prospective Matched Cohort Study
Andreas D Knudsen1,2, Andreas Fuchs2, Thomas Benfield3
1Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Background:
Persons with HIV (PWH) have an elevated risk of myocardial infarction compared to the general population. However, the underlying mechanisms linking HIV with this increased risk remain unclear. We aimed to compare the prevalence and characteristics of subclinical coronary atherosclerosis in PWH with population controls.
Methods:
Participants were included from the Copenhagen Comorbidity in HIV Infection study and the Copenhagen General Population Study. Presence of any and obstructive subclinical coronary atherosclerosis (≥50% stenosis) were assessed using coronary computed tomography angiography. Analyses were adjusted for cardiovascular risk factors including age, sex, hypertension, dyslipidemia, current smoking, overweight or obesity, and diabetes.
Results:
We included 519 PWH and 1114 age and sex-matched population controls. The median age was 52 years, and 89% of participants were men. The cardiovascular risk, evaluated by the Systematic COronary Risk Evaluation 2 prediction algorithm, was similar in PWH and population controls. PWH exhibited a higher prevalence of both any (54% vs 42%, P < .001) and obstructive coronary atherosclerosis (16% vs 8%, P < .001) than population controls. After adjusting for cardiovascular risk factors, HIV was associated with an odds ratio of 1.98 [95% confidence interval, 1.52-2.58] of any coronary atherosclerosis, and odds ratio of 3.21 [2.00-5.17] of obstructive atherosclerosis.
Conclusions:
HIV is independently associated with a three-fold higher risk of subclinical obstructive coronary atherosclerosis. Our results offer a possible explanation for the higher risk of myocardial infarction observed in PWH.
More Related Videos
13:58Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
14:23A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Related Concept Videos
Coronary Artery Disease III: Clinical Manifestations
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Acute Coronary Syndrome III: Diagnostic Studies
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies