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Updated: Sep 17, 2025
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
Thermoresponsive Biodegradable Hydrogel Combined with Photothermal and Chemodynamic Therapies To Eliminate Biofilms
Zehui Xiao1, Jiangli Cao1, Chumin Zhao1
1State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, PR China.
Abstract:
Bacterial wound infection tends to cause intense inflammation, while a lack of oxygen can lead to the destruction and contraction of blood vessels in the wound microenvironment. Here, a degradable hydrogel (denoted as PBCB hydrogel) was constructed with gelatin methacrylate (GelMA), tannic acid (TA), and polyphosphate (PolyP) by photopolymerization, and mesoporous polydopamine nanoparticles (MPDA) with berberine (BR), along with Cu and Bi nanoparticles grown in situ, were loaded into the hydrogel. PBCB hydrogel exhibits a high photothermal conversion efficiency (68.3%). Along with the degradation of the hydrogel, PolyP that was released showed a pronounced hemostatic effect in the mouse bleeding model by activating the clotting pathway. Under irradiation, PBCB hydrogel could constantly release BR, Cu2+, and TA, and 99.34% of methicillin-resistant Staphylococcus aureus (MRSA) and 99.82% of Escherichia coli (E. coli) were killed in vitro. In vitro experiments indicated that the PBCB hydrogel is capable of inhibiting and dismantling biofilm formation, as well as attenuating the expression of virulence factors. In vivo experimental data revealed that PBCB hydrogel-mediated synergistic chemodynamic therapy and photothermal therapy had a great promotional effect on wound sterilization and recovery. Our work demonstrated that the PBCB hydrogel can be used for bacterial biofilm removal and wound hemostasis, disinfection, and healing.
