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Updated: Sep 17, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
NCS-Mediated Direct Synthesis of β-Chlorosulfoxides from Unactivated Alkenes and Thiophenols
Jin Zhang1, Minlong Deng1, Zihan Cheng1
1School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, Shandong, P. R. China.
Abstract:
We report a streamlined one-pot methodology for the efficient synthesis of β-chlorosulfoxides from unactivated alkenes and aryl thiophenols using environmentally benign ethyl acetate as the reaction medium. The protocol utilizes N-chlorosuccinimide (NCS) in a dual capacity as both chlorine donor and intrinsic oxidant, thereby eliminating hazardous hydrochloric acid and external oxidizing agents. The scalability and reduced environmental impact position this strategy as a practical alternative to traditional multistep approaches.
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