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Updated: Sep 17, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Empowering heart attack treatment for women through machine learning and optimization techniques
Doaa Sami Khafaga1, Marwa M Eid2, El-Sayed M El-Kenawy3
1Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
This study introduces an optimized ensemble learning model for accurate heart attack detection in women. The novel Waterwheel Plant Algorithm (WWPA) with Stochastic Fractal Search (SFS) achieved 97.01% accuracy, improving cardiovascular care.
Area of Science:
- Cardiovascular Medicine
- Artificial Intelligence
- Machine Learning
Background:
- Heart attack diagnosis in women is often delayed or incorrect due to unique symptom presentation and physiology.
- Existing diagnostic models require optimization to address sex-specific differences in cardiovascular disease.
Purpose of the Study:
- To develop and validate an optimized ensemble learning model for enhanced heart attack classification accuracy in women.
- To integrate novel optimization algorithms for improved diagnostic performance in cardiovascular care.
Main Methods:
- An ensemble learning approach using a voting classifier combining the Waterwheel Plant Algorithm (WWPA) and Stochastic Fractal Search (SFS).
- Integration of multiple machine learning classifiers (Gaussian Naive Bayes, Random Forest, Logistic Regression, SGD, SVC, Decision Tree, k-NN).
- Evaluation on a clinical dataset of 303 patients with 14 features, using 10-fold cross-validation, ANOVA, and Wilcoxon Signed Rank Test.
Main Results:
- The proposed WWPA+SFS model achieved a highest classification accuracy of 97.01%.
- The model demonstrated robust performance and low variance across multiple trials.
- Outperformed other optimization algorithms including GWO, WOA, PSO, and GA.
Conclusions:
- The WWPA+SFS ensemble learning model significantly optimizes heart attack detection accuracy in women.
- This approach holds potential for reducing misdiagnosis rates, lowering healthcare costs, and advancing personalized cardiovascular treatment.
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