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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Autoimmune Cytopenias in Chronic Lymphocytic Leukemia
Candida Vitale1, Andrea Ferrario2, Giulia Zamprogna2
1Hematology Section, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy; Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
None:
Autoimmune phenomena, particularly autoimmune cytopenias (AIC), are common complications in patients with chronic lymphocytic leukemia (CLL), arising from the interplay of predisposing genetic and immunologic conditions and extrinsic triggering factors, such as infections and drugs. In this article, we provide insights into the pathogenesis of CLL-associated AIC, discuss diagnostic criteria and treatment recommendations, and present the most recent data on the impact of targeted agents on the management of AIC.
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