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CFM-UNet: coupling local and global feature extraction networks for medical image segmentation
Ke Niu1, Jiacheng Han2, Jiuyun Cai2
1Beijing Information Science and Technology University, Computer School, Beijing, 100000, China. niuke@bistu.edu.cn.
Scientific Reports
|July 2, 2025
Summary
This study introduces a hybrid CNN-Mamba U-Net for medical image segmentation, enhancing local and global feature extraction. The proposed CFM-UNet achieves superior performance across various medical imaging datasets.
Area of Science:
- Medical Image Analysis
- Deep Learning Architectures
- Computer Vision
Background:
- Convolutional Neural Networks (CNNs) excel at local feature extraction in medical imaging but struggle with global context.
- Mamba networks capture long-range dependencies but may miss fine spatial details.
- A hybrid approach is needed to combine CNN and Mamba strengths for improved medical image segmentation.
Purpose of the Study:
- To develop a novel hybrid deep learning model, CNN-Fusion-Mamba-based U-Net (CFM-UNet), for enhanced medical image segmentation.
- To integrate CNNs for local feature extraction and Mamba for global feature extraction within a U-Net framework.
- To evaluate the performance and generalization ability of CFM-UNet on diverse medical imaging datasets.
Main Methods:
- The proposed CFM-UNet integrates CNN-based Bottle2neck blocks for local feature learning.
- Mamba-based visual state space blocks are incorporated for global feature extraction.
- A novel Spatial-channel Excitation Fusion (SEF) block is designed for effective feature fusion between parallel CNN and Mamba pathways.
Main Results:
- CFM-UNet demonstrated superior performance compared to existing advanced methods on multiple medical image segmentation tasks.
- The model achieved high accuracy in segmenting liver organs, liver tumors, spine, and colon polyps.
- CFM-UNet exhibited strong generalization capabilities, particularly in liver organ segmentation.
Conclusions:
- The proposed CFM-UNet effectively combines the complementary strengths of CNNs and Mamba for medical image segmentation.
- This hybrid architecture significantly improves segmentation accuracy and robustness.
- CFM-UNet represents a promising advancement in automated medical image analysis.

