Impact of image averaging on choroidal quantification using swept-source optical coherence tomography.
Xiaotian Wu1,2, Yinglong Lan1,2, Peifeng Zhang1,2
1Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China.
BMC Ophthalmology
|July 2, 2025
Summary
B-scan averaging in swept-source optical coherence tomography (SS-OCT) impacts choroidal parameters. While choroidal vascularity index (CVI) is stable, luminal volume (LV), total choroidal volume (TCV), and choroidal thickness (CT) require at least 16 averaged frames for consistency.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Swept-source optical coherence tomography (SS-OCT) is crucial for choroidal imaging.
- Understanding the impact of image acquisition parameters like B-scan averaging is vital for reliable quantitative analysis.
Purpose of the Study:
- To evaluate how B-scan averaging affects key choroidal parameters measured by SS-OCT.
- To determine the optimal number of averaged frames for stable and reproducible measurements of choroidal volume and thickness.
Main Methods:
- Healthy adult eyes underwent SS-OCT imaging with varying B-scan averaging frames (4, 8, 16, 32, 64).
- Choroidal images were analyzed using binarization to quantify luminal volume (LV), stromal volume (SV), choroidal vascularity index (CVI), total choroidal volume (TCV), and choroidal thickness (CT).
Main Results:
- Choroidal vascularity index (CVI) showed no significant changes with averaging.
- Luminal volume (LV), total choroidal volume (TCV), and choroidal thickness (CT) required averaging of at least 16 frames for stability.
- Stromal volume (SV) achieved stability with averaging of at least 8 frames.
Conclusions:
- B-scan averaging significantly influences SS-OCT measurements of LV, SV, TCV, and CT, but not CVI.
- A minimum of 16 averaged frames is recommended for reliable LV, TCV, and CT measurements.
- Standardized B-scan averaging protocols are essential for consistent clinical application of SS-OCT in choroidal analysis.
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