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Targeted Cancer Therapies

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Related Experiment Video

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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG

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Pediatric Diffuse High-Grade Gliomas: A Comprehensive Review Of Ad-vanced Methods Of Diagnosis And Treatment.

Roja Rani Budha¹, Saba Wahid Khan¹, Deep Chandraprakash Sharma¹

¹H.K. College of Pharmacy, Oshiwara, Jogeshwari (W), Mumbai-400102, Maharashtra, India.

Current Cancer Drug Targets

|July 2, 2025

Summary

Pediatric Glioblastoma Multiforme (GBM) diagnosis and treatment are challenging due to its aggressive nature and molecular heterogeneity. Advanced MRI and new therapies offer hope, but further research is crucial for better outcomes.

Keywords:

MRI PET Pediatric diffuse high-grade glioma (pHGG)imaging technique.ionizing radiation tumor

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Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

Area of Science:

Neuro-oncology
Pediatric oncology
Radiology

Background:

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with significant diagnostic and therapeutic challenges, especially in pediatric patients.
Understanding its pathogenesis, molecular biology, symptoms, and imaging is crucial for effective treatment strategies.

Purpose of the Study:

To review current knowledge on pediatric GBM (also known as Pediatric Diffuse High-Grade Gliomas or pHGG).
To focus on the diagnosis and treatment of pediatric GBM, highlighting advancements and challenges.

Main Methods:

Comprehensive review of current literature on pediatric GBM.
Analysis of diagnostic techniques, including advanced Magnetic Resonance Imaging (MRI) methods like diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI).
Examination of emerging therapeutic approaches such as targeted therapies and immunotherapy, alongside standard treatments.

Main Results:

Pediatric GBM typically originates in the cerebral hemispheres, exhibiting heterogeneous morphology and aggressive cell populations.
Genomic research has identified distinct molecular pathways in primary and secondary GBMs.
Advanced MRI techniques provide critical insights into tumor microstructure and vascularity, aiding in diagnosis and response assessment.

Conclusions:

Accurate diagnosis and management of pediatric GBM remain challenging due to molecular heterogeneity and unique biological behavior.
Novel therapeutic strategies, including targeted therapies and immunotherapy, show promise for improving outcomes.
A multidisciplinary approach and ongoing clinical trials are essential for optimizing treatment and advancing care for pediatric GBM patients.