Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

8.9K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
8.9K
Enzymes02:34

Enzymes

82.8K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
82.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-based frame synthesis enables radiation dose reduction in digital subtraction angiography imaging: a multicenter study.

Frontiers in medicine·2026
Same author

Case Report: A novel strategy for superior petrosal vein management in cerebellopontine angle surgery.

Frontiers in oncology·2026
Same author

The vertebro-subclavian artery angle modulates hemodynamic mechanisms of atherosclerosis in vertebral artery origin: a combined clinical and computational fluid dynamics study.

Frontiers in bioengineering and biotechnology·2026
Same author

Synthetic lethality in cancer: mechanism exploration and therapeutic applications.

Cell communication and signaling : CCS·2026
Same author

Defect-Rich RuCu Multilayered Nanosheets for Effective Alkaline Hydrogen Electrocatalysis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The transcription factor OsWRKY36 regulates leaf angle in rice by modulating brassinosteroid signaling.

The Plant cell·2026
Same journal

Ordered Polar Topological Domains Enabling Giant Second-Harmonic Generation in Ferroelectric Nematic Liquid Crystals.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Dual-Functional Alumina Additive Enabling Efficient, Volumetric Mechanoluminescence for Nighttime Safety Footwear.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Phase Transformation Accompanied by Evolution of Internal Stress and the Coupling Mechanism of Chemical-Mechanical Degradation in Single-Crystal NiRich Cathodes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Zwitterionic Polymer Electrolytes With Dipole-Rotation-Assisted Ion Conduction for Solid Lithium Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

3D-Printed Ultra-Thin Solid Polymer Electrolytes with Superior Dielectric Properties for Wide Temperature Range All-Solid-State Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Electrostatic Potential Tuning by Low-Volatility Halogenated Additive: Boosting PTQ10-Based Binary OPV to Near 20% Efficiency with High Scalability.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Sep 17, 2025

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

10.9K

Spatial Coordination Structure-Driven Enzyme-Like Selectivity in Single-Atom Nanozymes.

Qijun Sun1,2, Si Liu1, Ziping Li1

  • 1School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, NSW, 2052, Australia.

Advanced Materials (Deerfield Beach, Fla.)
|July 2, 2025
PubMed
Summary
This summary is machine-generated.

Single-atom nanozymes (SAzymes) offer robust catalysis but lack selectivity. This review highlights designing coordination structures to enhance SAzyme selectivity for enzyme-like reactions.

Keywords:
coordination structuredensity functional theoryenzyme‐like catalytic selectivitysingle‐atom nanozymes, support

More Related Videos

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System
12:30

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System

Published on: February 9, 2017

12.3K
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K

Related Experiment Videos

Last Updated: Sep 17, 2025

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

10.9K
Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System
12:30

Structural Information from Single-molecule FRET Experiments Using the Fast Nano-positioning System

Published on: February 9, 2017

12.3K
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

6.8K

Area of Science:

  • Nanomaterials Science
  • Catalysis
  • Biochemistry

Background:

  • Single-atom nanozymes (SAzymes) mimic natural enzymes with high activity and atom utilization.
  • Current SAzymes exhibit limited catalytic selectivity due to simplified structures compared to natural enzymes.
  • Enhancing SAzyme selectivity is crucial for their broader application as enzyme replacements.

Purpose of the Study:

  • To review strategies for improving the catalytic selectivity of SAzymes.
  • To focus on the rational design of spatial coordination structures in SAzymes.
  • To analyze structure-activity relationships and synthesis methods for selective SAzymes.

Main Methods:

  • Reviewing literature on SAzyme coordination structure design.
  • Analyzing structure-activity relationships for selective catalysis.
  • Examining synthesis approaches for tailored SAzyme structures.

Main Results:

  • Spatial coordination structures significantly influence SAzyme selectivity.
  • Rational design of coordination environments can achieve targeted enzyme-like selectivity.
  • Specific synthesis methods enable the integration of designed structures onto supports.

Conclusions:

  • Designing coordination structures is key to unlocking SAzyme selectivity.
  • Further research into SAzyme coordination structures will drive the development of next-generation catalysts.
  • Overcoming challenges in structure control and synthesis is essential for advancing SAzyme technology.