Histologic Study of Abdominal Skin Treated With Mechanical Dermal Micro-Coring Technology for Minimally Invasive Skin...

Area of Science:

• Dermatology
• Aesthetic Medicine
• Histopathology

Background:

• Mechanical Dermal Micro-Coring Technology (MCT) utilizes hollow needles for direct skin core excision.
• This process aims to induce skin tightening and wrinkle reduction through the body's natural wound-healing response and collagen stimulation.

Purpose of the Study:

• To histopathologically and immunohistochemically evaluate skin and subcutaneous tissue changes following single and multiple MCT treatments.
• Assessing the dermal and subcutaneous tissue response to Mechanical Dermal Micro-Coring Technology.

Main Methods:

• A single-center pilot study involving 6 female patients undergoing abdominoplasty.
• Two cohorts were established: Cohort 1 received single treatments at varying depths (4-7mm), with 30-day tissue sampling. Cohort 2 received 1-3 treatments at 4mm depth with 30-day intervals, with 90-day tissue sampling.
• Histopathology utilized H&E, Herovici, and Movat stains, with blinded evaluation.

Main Results:

• A significant increase in new collagen was observed in all treated samples compared to controls.
• Histological analysis revealed no evidence of inflammation or scarring post-treatment.
• Consistent findings with previous preclinical and clinical histological assessments of MCT.

Conclusions:

• MCT treatment leads to increased collagen production and dermal homogenization in the treated areas.
• Histological findings support MCT's efficacy beyond mere skin removal, promoting tissue remodeling.
• The technology demonstrates a favorable histological profile, indicating potential for skin rejuvenation and tightening.