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Morusin Suppresses Pancreatic Cancer Cell Proliferation and Migration by Targeting SLC6A12 to Inhibit NF-κB and

Wenyan Yang1,2, Wei Zhu3, Zhiyang Yao1,2

  • 1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.

Recent Patents on Anti-Cancer Drug Discovery
|July 2, 2025
PubMed
Abstract

Insights

Morusin demonstrates significant anticancer effects against pancreatic cancer by inhibiting cell proliferation, migration, and invasion. It also induces apoptosis and targets SLC6A12, offering potential as a novel therapeutic agent.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Pancreatic cancer has a poor prognosis, necessitating new therapeutic strategies.
  • Morusin exhibits known anticancer properties across various cancer types.
  • This study investigates Morusin's efficacy and mechanisms in pancreatic cancer.

Purpose of the Study:

  • To evaluate the anticancer effects of Morusin on pancreatic cancer cells.
  • To elucidate the molecular mechanisms underlying Morusin's anti-pancreatic cancer activity.
  • To identify potential therapeutic targets for Morusin in pancreatic cancer treatment.

Main Methods:

  • Assessed Morusin's impact on pancreatic cancer cell proliferation, colony formation, migration, and invasion.
  • Analyzed cell cycle progression and apoptosis induction following Morusin treatment.
  • Utilized RNA sequencing (RNA-seq), RT-qPCR, and Western blot to identify and verify key genes and pathways.

Main Results:

  • Morusin significantly inhibited pancreatic cancer cell proliferation, migration, and invasion.
  • Morusin induced apoptosis and disrupted cell cycle progression in pancreatic cancer cells.
  • Morusin modulated SLC6A12 expression and inhibited NF-κB and β-catenin signaling pathways.

Conclusions:

  • Morusin exhibits potent anti-pancreatic cancer activity.
  • Targeting SLC6A12 and associated signaling pathways are key mechanisms of Morusin's action.
  • Morusin shows promise as a potential therapeutic agent for pancreatic cancer.
Keywords:
MorusinNF-κBSLC6A12pancreatic cancerproliferationβ-catenin

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