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Related Experiment Videos

Levamisole toxicosis in swine.

W O Cook, G D Osweiler, W Hyde

    Veterinary and Human Toxicology
    |October 1, 1985
    PubMed
    Summary

    Levamisole toxicosis in swine resulted from accidental intramuscular injection. Clinical signs included vomiting, ataxia, and death, with survivors recovering within 48 hours.

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    Area of Science:

    • Veterinary Toxicology
    • Swine Medicine
    • Pharmacology

    Background:

    • Levamisole is an anthelmintic and immunomodulator used in veterinary medicine.
    • Accidental overdosing or misadministration can lead to toxicosis.
    • Swine operations require strict adherence to drug administration protocols.

    Observation:

    • A commercial swine operation reported cases of toxicosis following intramuscular injection of levamisole.
    • Animals exhibited clinical signs such as vomiting, salivation, ataxia, and recumbency.
    • Mortality was observed in some affected animals.

    Findings:

    • The toxicosis was directly linked to the intramuscular administration of levamisole.
    • Clinical manifestations were consistent with known levamisole toxicity syndromes.
    • Complete recovery occurred in surviving pigs within 24 to 48 hours post-exposure.

    Implications:

    • Highlights the critical importance of accurate drug identification and administration in swine husbandry.
    • Emphasizes the need for veterinary oversight and staff training to prevent medication errors.
    • Underscores the potential for rapid onset of severe clinical signs and mortality in levamisole toxicosis in swine.

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