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Updated: Sep 17, 2025

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
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[Polyneuropathies - a practical overview].

Marisa Blanquet1,2, Andrea M Humm1,3

  • 1Neuromuskuläres Zentrum, Universitätsklinik fur Neurologie, Inselspital Bern, Bern.

Therapeutische Umschau. Revue Therapeutique
|July 3, 2025
PubMed
Summary
This summary is machine-generated.

Polyneuropathies present diverse symptoms and causes. This guide offers a practical approach to diagnosis and treatment, highlighting red flags for urgent specialist referral.

Keywords:
Polyneuropathy (PNP)mononeuritis multiplexpolyradiculoneuropathysmall-fiber neuropathy (SFN)

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Area of Science:

  • Neurology
  • Clinical Medicine

Background:

  • Polyneuropathies are prevalent neurological disorders with varied clinical manifestations.
  • Numerous underlying etiologies contribute to the development of polyneuropathies.

Purpose of the Study:

  • To provide a practice-oriented overview of polyneuropathy symptoms and causes.
  • To outline a systematic, step-by-step diagnostic strategy for polyneuropathies.
  • To emphasize the identification of red flags necessitating prompt specialist evaluation and to briefly discuss treatment options.

Main Methods:

  • Literature review and synthesis of current clinical guidelines.
  • Analysis of diagnostic criteria and red flag indicators.
  • Summary of established and emerging treatment modalities.

Main Results:

  • Detailed description of common and uncommon polyneuropathy symptoms.
  • Categorization of major etiological factors, including metabolic, toxic, infectious, and hereditary causes.
  • Presentation of a structured diagnostic algorithm incorporating clinical examination, laboratory tests, and electrophysiological studies.

Conclusions:

  • Early identification of specific symptoms and red flags is crucial for timely diagnosis.
  • A systematic diagnostic approach ensures comprehensive evaluation of polyneuropathies.
  • Appropriate management based on etiology leads to improved patient outcomes.