Related Experiment Video
Updated: Sep 17, 2025
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
The Effect of Transcranial Direct Current Stimulation and Inhibitory Control Training on Working Memory in Post-stroke
Csaba Kazinczi1,2, Noemi Szepfalusi1, Viola Luca Nemeth1
1University of Szeged, Department of Neurology; 6, Semmelweis Street, Szeged 6725, Hungary.
Aim:
The impairment of working memory is a common phenomenon after stroke and critically affects daily functioning. Transcranial direct current stimulation and computer- based cognitive training are widely used in neurorehabilitation to enhance cognitive functions. This study examined the single vs combined effect of anodal stimulation and computer-based inhibitory control training on working memory function among post-stroke patients.
Methods:
Thirty-five participants were randomly allocated to receiving either active stimulation, sham stimulation with training, or active stimulation with training. Forward/ Backward Digit Span Task, Listening Span Task, Corsi Block Tapping Task, and Trail Making Test were used to assess working memory functions at baseline and after the ten-session experimental program. For statistical analysis, we performed a Linear Mixed-effects Model.
Results:
A significant group-by-time interaction showed in favour of the combined group over the active stimulation group in the case of forward digit span (p=.028).
Conclusion:
Results indicate that cognitive training and stimulation solely did not lead to significant improvements in working memory related functions among post-stroke patients. However, the combined application may be favourable. The effectiveness of cognitive training and transcranial direct current stimulation needs further examination. (Neuropsychopharmacol Hung 2025; 27(2): 88-105)
