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Evaluating the Immune Response After Targeted Radionuclide Therapy: Toward a Correlation Between Absorbed Dose and
Justine Perrin1, Nina Overdevest1, Giulia Tamborino1
1Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Targeted radionuclide therapy (TRT) shows potential for cancer treatment by activating CD8+ T cells. Further research is needed to optimize TRT dose and dose rate for effective immune response and combination therapies.
Area of Science:
- Oncology
- Immunology
- Radiotherapy
Background:
- Targeted radionuclide therapy (TRT) is clinically successful for neuroendocrine and prostate cancers, but curative outcomes are limited.
- The immunogenic potential of TRT and its synergy with immunotherapy are underexplored compared to external beam radiation therapy.
Purpose of the Study:
- To evaluate the immunogenicity of TRT by reviewing literature.
- To assess the relationship between absorbed dose, dose rate, and immune response in TRT.
Main Methods:
- Conducted a literature review on immune response following TRT.
- Calculated absorbed dose and dose rate in vivo and in vitro for various TRT strategies.
- Assessed correlations between dosimetric parameters and immune changes.
Main Results:
- A strong correlation was found between absorbed dose from TRT and CD8+ T cell activation.
- Maximum dose rate showed a nonsignificant association with dendritic cell and macrophage infiltration.
- Precise dosimetry and dose delivery kinetics are crucial for predicting TRT-induced immunogenicity.
Conclusions:
- TRT demonstrates immunogenic potential, but optimal absorbed dose and dose rate require further investigation.
- Understanding these parameters is vital for advancing combination therapies with immunotherapy.
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