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Human Skin Models in Biophotonics: Materials, Methods, and Applications.

Dardan Bajrami1,2,3, Fabrizio Spano2, Kongchang Wei1,4

  • 1Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Empa, Lerchenfeldstrasse 5, St.Gallen, 9014, Switzerland.

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|July 7, 2025
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Summary
This summary is machine-generated.

This review details in vitro optical skin models that mimic human skin's complex light interactions. These models are crucial for advancing biophotonic applications and reducing animal testing in research and development.

Keywords:
biophotonicsphotonicsskinskin modelsskin phantomstissue models

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Area of Science:

  • Biophotonics
  • Biomaterials Science
  • Optical Engineering

Background:

  • Human skin possesses intricate optical properties governing light absorption, scattering, and reflection.
  • These properties are vital for biophotonic applications like diagnostics, imaging, and therapy.
  • In vitro replication of skin optics is essential for developing advanced optical skin models.

Purpose of the Study:

  • To review the fundamental optical properties of human skin.
  • To outline principles and materials for replicating skin optics in vitro.
  • To categorize and discuss state-of-the-art optical skin models and their applications.

Main Methods:

  • Review of existing literature on human skin optics and in vitro model fabrication.
  • Analysis of materials (absorbers, scatterers, matrices) used in model development.
  • Categorization of models based on structural complexity and functionality.

Main Results:

  • Discussion of various strategies for fabricating optical skin models.
  • Exploration of models incorporating additional physical and biological components.
  • Highlighting the current capabilities of advanced optical skin models.

Conclusions:

  • Optical skin models are critical for studying light-skin interactions under controlled conditions.
  • These models reduce reliance on animal testing and promote standardized research.
  • Future models will support personalized biophotonic tools and advanced light-based therapies.