Highly Sensitive Electrochemical Detection of Pomalidomide Using a Novel NiCuSe₂/MnCoFe LTH Nanocomposite Sensor:...

A novel electrochemical sensor for the quantification of Pomalidomide (POMA) is introduced in the present work, based on a glassy carbon electrode (GCE) modified with a unique NiCuSe₂/MnCoFe layered triple hydroxide (LTH) composite. In this regard, the novel NiCuSe₂/MnCoFe LTH composite was synthesized and characterized using various structural and morphological techniques, confirming its successful formation. The electrochemical properties of the composite were evaluated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), providing its high conductivity, superior electrocatalytic activity, and rapid electron transfer capabilities. The NiCuSe₂/MnCoFe LTH-modified GCE was utilized for the detection and quantification of POMA using differential pulse voltammetry (DPV). The developed sensor exhibited an impressive linear detection range of 0.02-10.3 μM and an ultralow detection limit of 4.7 nM. Furthermore, it demonstrated exceptional selectivity, reproducibility, and repeatability. Finally, the sensor was applied to analyze POMA in some real samples: pharmaceutical capsules, human urine, and human blood serum.