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Updated: Sep 16, 2025

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Ti-Catalyzed Functional Group Tolerant and Regioselective Cross Couplings of (Hetero)aryl Grignard Reagents with
Jin-Long Zhao1, Jun-Ting Li1, Jing-Yan Kong1
1College of Chemistry, Beijing Normal University, Beijing 100875, China.
Abstract:
We report an unprecedented Ti-catalyzed functional group tolerant and regioselective coupling reaction where (hetro)aryl Grignard reagents are coupled with halopyridines and haloquinolines through an SRN pathway. A simple titanate catalyst not only triggered radical anion generation and the corresponding SRN couplings but also enabled high functional group tolerance and regioselectivity. Highly electron-deficient functionalized Grignard reagents were quite involved in such reactions, and a variety of valuable arylpyridines, bipyridines, and terpyridines were assembled facilely.
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