Related Experiment Video
Updated: Sep 16, 2025
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.4K
Effects of fasting on HDL particle function and size distribution.
Joanne Agus1, Angela M Zivkovic1
1Department of Nutrition, University of California, Davis, CA, USA.
Journal of Lipid Research
|July 7, 2025
Summary
Fasting
Area of Science:
- Lipid metabolism and cardiovascular health research.
Background:
- High-density lipoprotein (HDL) particle function is crucial for cardiovascular health.
- The impact of various fasting regimens on HDL particles requires further elucidation.
Purpose of the Study:
- To review the current evidence on how intermittent fasting (IF) and continuous fasting (CF) affect HDL cholesterol (HDL-C), particle concentration, and size distribution.
- To identify limitations and inconsistencies in existing research regarding fasting and HDL particles.
Main Methods:
- A narrative review of existing scientific literature on fasting and HDL particles.
- Analysis of studies employing intermittent fasting (IF) and continuous fasting (CF) protocols.
- Examination of reported changes in HDL-C, HDL particle size, and concentration.
Main Results:
- Evidence on fasting's impact on HDL particles is limited and inconsistent, especially for IF.
- Confounding factors like weight loss in IF studies complicate the interpretation of HDL changes.
- Continuous fasting (CF) studies show a mild trend towards decreased HDL-C and altered particle distribution, but health implications are unclear.
Conclusions:
- The precise effects of fasting on HDL particles are not well-established.
- Further research is necessary to understand the health implications of fasting-induced changes in HDL particles.
Keywords:
Intermittent fastinghigh density lipoproteinparticle concentrationprolonged fastingsize distributionMore Related Videos
Related Concept Videos
01:24Metabolic States of the Body: Fasting and Starvation
1.8K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.8K
01:29Cholesterol: Significance and Regulation
697
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
697
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
298
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
298
01:18Metabolic States of the Body: The Postabsorptive State
558
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
558
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
879
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
879