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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Di- and Tetranuclear Cationic Silver(I) Complexes Bearing Bis(diphenylphosphino)pyridine Ligands: Synthesis,
Bhagyashree Das1, Saiprada Sourav Dehuri1, Bedadyuti Vedvyas Pati2
1Department of Chemical Sciences, Indian Institute of Science Education and Research Berhampur (IISER BPR), Transit Campus, Industrial Training Institute, Engineering School Road, Berhampur, Odisha 760010, India.
Abstract:
A series of di- and tetranuclear silver(I) complexes featuring (BPPMP)E2 [BPPMP: bis(diphenylphosphinomethyl)pyridine] and (BPPP)E2 [BPPP: bis(diphenylphosphino)pyridine] (2a/6a, E = S; 2b/6b, E = Se) species have been isolated and utilized in cyclization reactions. The reactions of (BPPP)E2 and (BPPMP)E2 (2a/6a, E = S; 2b/6b, E = Se) with various silver salts afforded the corresponding cationic complexes of the type [(2a/2b)3Ag4(CH3CN)3][X]4 (3/4, X = BF4 and SbF6) and [(6a/6b)Ag]2[BF4]2 (7a/7b) as bench-stable solids. The solid-state structures of tetranuclear silver complexes do not exhibit metal-metal interactions; however, the corresponding dinuclear silver complexes (7) display intramolecular argentophilic (Ag···Ag) interactions. Subsequently, the molecular catalytic performances of bench-stable 3a and 7a were explored in the preparation of biologically active polysubstituted 1,3-dihydronaphtho[2,3-c]furan and aminoindolizine derivatives, respectively, with high atom-economic pathways and achieved good to excellent yields by solvent- and additive-free approaches. The newly developed protocols in this study demonstrate a broad substrate scope and utilize nontoxic and cost-effective silver-based molecular catalysts.
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