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Early Vitrectomy in Endophthalmitis: Visual Outcomes and Complication Rates
Julian W Sromicki1, Marc Stahel1, Robert A Blum1
1Department of Ophthalmology, University Hospital and University of Zurich, Frauenklinikstrasse 24, 8091, Zurich, Switzerland.
Ophthalmology and Therapy
|July 9, 2025
Summary
Early pars plana vitrectomy (PPV) shows good visual outcomes for endophthalmitis after cataract surgery or intravitreal injection. Complication rates varied by cause, with trabeculectomy having the highest incidence.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Retinal Diseases
Background:
- Endophthalmitis poses a significant risk to vision following intraocular procedures.
- Early intervention is crucial for managing post-operative infections and preserving sight.
Purpose of the Study:
- To evaluate the visual outcomes and complication rates associated with early pars plana vitrectomy (PPV) in endophthalmitis cases.
- To compare outcomes based on the initial cause of endophthalmitis.
Main Methods:
- A retrospective observational study analyzed 92 eyes with endophthalmitis treated with early PPV.
- Data included visual acuity (VA) and intraocular pressure (IOP) before and up to 12 months after PPV.
- Endophthalmitis causes included cataract surgery, intravitreal injection, trabeculectomy, and others (trauma/endogenous).
Main Results:
- Eyes with endophthalmitis following cataract surgery (CAT) and intravitreal injection (IVI) demonstrated favorable visual outcomes.
- Final VA in CAT and IVI groups was comparable to pre-endophthalmitis levels.
- Complication rates were highest in the trabeculectomy group (100%), followed by others (63.3%), IVI (50.0%), and CAT (40.9%).
Conclusions:
- Early PPV appears beneficial for endophthalmitis, particularly after cataract surgery and intravitreal injections.
- The procedure may preserve or restore vision irrespective of the initial visual acuity.
- Risk stratification for complications is important, with certain procedures carrying higher risks.
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