Related Experiment Video
Updated: Sep 16, 2025
09:32
Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.3K
Nanocarriers in Atopic Dermatitis Therapy: A Comprehensive Exploration.
Meriem Rezigue1, Rasha M Bashatwah1, Khaled I Seetan2
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 21163, Jordan.
Pharmaceutical Nanotechnology
|July 11, 2025
Summary
Advanced nanocarriers offer new hope for atopic dermatitis (AD) treatment. These innovative systems improve drug delivery, enhance skin penetration, and reduce side effects for personalized AD therapy.
Area of Science:
- Dermatology and Nanotechnology
- Advanced Drug Delivery Systems
Background:
- Atopic dermatitis (AD) management requires improved topical therapies.
- Current treatments face challenges in efficacy and systemic exposure.
Purpose of the Study:
- To explore advanced nanocarriers for enhanced topical drug delivery in atopic dermatitis (AD).
- To evaluate the potential of various nanocarrier systems in revolutionizing AD treatment.
Main Methods:
- Review of lipid nanoparticles (SLN, NLC), vesicular systems (liposomes, ethosomes, transfersomes, niosomes), micro/nanoemulsions, polymeric nanoparticles, and metal nanoparticles (AuNPs, AgNPs).
- Assessment of their properties including drug release, skin penetration, targeting, and toxicity.
- Consideration of gene silencing (siRNA) and immunobiologics for targeted therapy.
Main Results:
- Nanocarriers demonstrate controlled release, enhanced skin penetration, and efficient drug encapsulation.
- Polymeric nanoparticles and metal nanoparticles offer targeted delivery and immune modulation.
- Skin lipids and advanced formulations can restore the skin barrier and reduce toxicity.
Conclusions:
- Advanced nanocarriers present significant opportunities for personalized AD treatment.
- These systems can reduce systemic exposure and improve therapeutic efficacy.
- Overcoming formulation challenges positions nanocarriers as key to redefining AD patient care.
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
471
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
471
01:22Drug Delivery: Miscellaneous Routes
471
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
471
01:19Antiasthma Drugs: Leukotriene Modifiers
489
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
489
01:20Asthma: Pathogenesis and Management
607
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
607
01:24Cholinergic Antagonists: Pharmacokinetics
565
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
565
01:23Local Anesthetics: Common Agents and Their Applications
559
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
559