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Updated: Sep 16, 2025

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
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Innate lymphoid cells originate from fetal liver-derived tissue-resident progenitors

Xianwei Wang1, Jiarui Li1, Lucas Rebuffet2

  • 1State Key Laboratory of Immune Response and Immunotherapy, the Institute of Immunology, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

Science Immunology
|July 11, 2025
PubMed
Summary

Innate lymphoid cell (ILC) development differs between fetal and adult origins. Fetal liver-derived precursors establish extramedullary ILCs independently of adult bone marrow hematopoiesis.

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