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Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples
Published on: January 13, 2023
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Advances in blood microsampling technology for cancer biomarker detection
Natasha Lucas1, Ben R Herbert2, Mark P Molloy3
1Sangui Bio Pty Ltd., Sydney, NSW, Australia; School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia; Kolling Institute of Medical Research, Sydney, NSW, Australia.
Advances in Clinical Chemistry
|July 11, 2025
Summary
Blood microsampling offers a promising, minimally invasive method for cancer diagnostics and monitoring. This technology is rapidly advancing, showing potential for improved biomarker stability and diverse
Area of Science:
- Biomedical Engineering
- Clinical Diagnostics
- Biomarker Discovery
Background:
- Blood microsampling is established for newborn screening, therapeutic drug monitoring (TDM), and viral detection.
- Its application in cancer diagnostics, including early detection and recurrence monitoring, is emerging.
- Innovations in microsampling devices and early studies indicate strong potential for clinical cancer applications.
Purpose of the Study:
- To review the opportunities and challenges of blood microsampling for cancer diagnostics.
- To discuss biomarker stability, particularly in dried blood spots for self-collected specimens.
- To highlight the integration of microsampling with various 'omics' fields for cancer biomarker research.
Main Methods:
- Literature review of current research in blood microsampling for cancer diagnostics.
- Analysis of opportunities and challenges in biospecimen collection and analysis.
- Examination of 'omics' applications (proteomics, metabolomics, genomics, etc.) with microsampling.
Main Results:
- Blood microsampling technology is rapidly innovating with significant potential for cancer diagnostics.
- Biomarker stability in dried blood spots is a critical factor for self-collected samples.
- 'Omics' fields show promise for microsampling applications in cancer biomarker discovery.
Conclusions:
- Blood microsampling presents a developing yet innovative solution for biospecimen collection challenges in cancer diagnostics.
- Further research and technological advancements are expected to enhance its clinical utility.
- The technology holds promise for improving early diagnosis, disease monitoring, and TDM in oncology.
