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First-line Therapy: Time-Limited Venetoclax Doublet Therapy
Jennifer Huang1, Mazyar Shadman1
1Clinical Research Division, Fred Hutch Cancer Center, Seattle, WA, USA; Division of Medicine, University of Washington, Seattle, WA, USA.
None:
Studies examining venetoclax in combination with anti-CD20 monoclonal antibodies and covalent Bruton tyrosine kinase inhibitors (BTKi) demonstrated a progression-free survival and in some cases overall survival benefit over chemoimmunotherapy. It is currently unclear what is the most optimal combination partner for a B-cell leukemia/lymphoma 2 inhibitor (BCL2i). We are eagerly awaiting results from studies to determine the most effective BCL2i and BTKi combination for the first-line treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma given the development of second-generation drugs.
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