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Updated: Sep 16, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Synthesis of Polysubstituted Cyclohexenes via Pyridine-Boryl Radical-Catalyzed Formal [4 + 2] Cycloadditions of
Hua Huang1, Yun-Xuan Tan1, Ping Tian1
1State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Abstract:
Polysubstituted cyclohexene derivatives widely exist in pharmaceuticals and bioactive natural products. Herein, we report the first pyridine-boryl radical-catalyzed intermolecular formal [4 + 2] cycloadditions between cyclobutanes and alkynes, producing tri- and tetrasubstituted cyclohexene derivatives with a broad substrate scope and moderate to high yields. Moreover, the intramolecular formal [4 + 2] cycloaddition of alkyne-tethered cyclobutanes has also been achieved.
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