Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Macronutrient Deprivation on Spring Wheat Productivity.

Plants (Basel, Switzerland)·2026
Same author

Referral for glaucoma surgery and types of surgery in different European regions in 2025, the EURACCUR study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

First-in-Human Prospective, Observational, and Comparative Clinical Study of Simultaneous Invasive and Non-Invasive Intracranial Pressure Pulse Wave Monitoring.

Sensors (Basel, Switzerland)·2026
Same author

Significance of Peripheral Perfusion Changes During Remote Ischemic Conditioning in Critically Ill Patients.

Journal of clinical medicine·2026
Same author

Novel mode of heart and lung machine for real-time identification of cerebral autoregulation impairments during cardiac surgery with cardiopulmonary bypass: a prospective observational study.

Minerva anestesiologica·2025
Same author

Delirium after coronary artery bypass grafting with cardiopulmonary bypass surgery: The value of cerebral autoregulation.

Perfusion·2025

Related Experiment Video

Updated: Sep 16, 2025

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K

A Novel Approach to Non-Invasive Intracranial Pressure Wave Monitoring: A Pilot Healthy Brain Study.

Andrius Karaliunas1, Laimonas Bartusis1, Solventa Krakauskaite1

  • 1Health Telematics Science Institute, Kaunas University of Technology, LT-51423 Kaunas, Lithuania.

Sensors (Basel, Switzerland)
|July 12, 2025
PubMed
Summary

This pilot study introduces a novel non-invasive method using the 'Archimedes 02' sensor to monitor intracranial pressure (ICP) pulse waves through closed eyelids. The system successfully detected ICP pulse waves, reflecting intracranial dynamics and compliance in healthy volunteers.

Keywords:
healthy volunteer studyintracranial complianceintracranial pressure wavesnon-invasive monitoringpulse wave morphology

More Related Videos

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.1K
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

2.5K

Related Experiment Videos

Last Updated: Sep 16, 2025

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
06:18

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

9.1K
A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.1K
Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

2.5K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Devices

Background:

  • Intracranial pressure (ICP) pulse wave morphology provides critical insights into brain compliance and dynamics.
  • Traditional invasive ICP monitoring methods carry significant risks, necessitating the development of non-invasive alternatives.
  • Current non-invasive techniques for ICP monitoring are limited, especially for continuous waveform analysis.

Purpose of the Study:

  • To investigate a novel non-invasive method for monitoring ICP pulse waves through closed eyelids using the 'Archimedes 02' sensor system.
  • To assess the feasibility and preliminary efficacy of this new technology in healthy volunteers.
  • To evaluate the correlation between non-invasively recorded pulse wave morphology and physiological challenges.

Main Methods:

  • A pilot study involving 10 healthy volunteers (aged 26-39) using the 'Archimedes 02' liquid-filled, passive sensor system.
  • Non-invasive ICP pulse wave monitoring sessions conducted through closed eyelids in a supine position.
  • Analysis of pulse wave morphology, including P2/P1 and P3/P1 ratios, before and during physiological maneuvers (Valsalva, Queckenstedt, hypoemic/hyperemic response tests).

Main Results:

  • Successful detection of intracranial pressure (ICP) pulse waves with characteristic peaks (P1, P2, P3) in all subjects.
  • Calculated P2/P1 ratios indicated normal intracranial compliance (Left: 0.762 ± 0.229, Right: 0.808 ± 0.310).
  • Physiological tests induced significant changes in pulse wave ratios, confirming reflection of intracranial volume and pressure dynamics. Cerebral blood flow autoregulation was also observed.

Conclusions:

  • The 'Archimedes 02' sensor system enables non-invasive monitoring of ICP pulse waves and their dynamic changes through closed eyelids.
  • This novel approach shows promise as a safe alternative for brain monitoring, particularly in patients unsuitable for invasive procedures.
  • The findings support the potential of this technology for real-time assessment of intracranial status and cerebrovascular regulation.