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Phage-Microbiota Crosstalk: Implications for Central Nervous System Disorders.
Valentina Salari1, Edoardo Parrella1,2, Francesca Mengoni1
1Section of Innovation Biomedicine, Department of Engineering for Innovation Medicine, University of Verona, 37134 Verona, Italy.
International Journal of Molecular Sciences
|July 12, 2025
Summary
This review explores the limited research on gut phages and the central nervous system (CNS). It examines the biological interactions between gut phages and the CNS, and their potential role in CNS disorders.
Area of Science:
- Microbiology
- Neuroscience
- Virology
Background:
- The gut microbiota is a complex community of microorganisms.
- The microbiota-gut-brain axis describes communication between gut microbes and the CNS.
- Gut phages are abundant but understudied in CNS contexts.
Purpose of the Study:
- To review the biological interplay between gut phages and the CNS.
- To discuss the current literature on phages and CNS pathologies.
Main Methods:
- Literature review of existing studies on gut phages and the CNS.
Main Results:
- Limited research currently exists on the relationship between gut phages and the CNS.
- Phages are a significant component of the gut microbial community.
Conclusions:
- Further research is needed to understand the role of gut phages in CNS health and disease.
- The gut microbiota-brain axis may involve phages in ways not yet fully understood.
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