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Updated: Sep 15, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Patterns and Outcomes of Limb Amputations: A Single-Center Retrospective Study
Saad M Alqahtani1, Omar Bamalan2, Hussain Aljubran1
1Department of Orthopedic Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Introduction:
Despite tremendous medical advancements, limb amputations are still considered a standard procedure performed worldwide. However, this procedure poses distinct challenges that can significantly affect the mental and physical well-being of patients. This study aimed to analyze the clinical characteristics of amputations and assess the quality of life among affected individuals.
Methods:
A retrospective single-center study of patients requiring limb amputations was performed. Patient demographics, clinical data, and outcomes were collected. Patient-reported outcomes using the Short Form-36 questionnaire were also documented. Descriptive statistics were analyzed, and P < 0.05 was considered statistically significant.
Results:
A total of 268 patients were included in the study, affected in between 2015 and 2021, with a mean age of 30 ± 24.7 years. Lower extremity amputations were the most commonly performed, and peripheral vascular disease was the most common underlying causes for amputation. Complications were encountered in 16.8% of cases, and 12.3% required revision procedures. Notably, lower extremity amputations due to peripheral vascular disease and more peripheral amputations (phalanx and metatarsal/carpal amputations) were significantly associated with a higher rate of complications. In addition, patients who encountered complications or required revisions were generally older. In terms of Short Form-36 scores, patients reported higher scores for health change (73 ± 29.7) and lower scores for role limitation due to personal or emotional problems (39.6 ± 47).
Conclusions:
A relatively high rate of complications and revisions was found in patients requiring amputations. This highlights the need for conducting a comprehensive postoperative assessment for these patients and adopting a multimodal approach to amputation care. Such an approach should not only focus on the surgical aspects but also encompass postoperative rehabilitation and address the emotional well-being of patients.

