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A Case of Persistent Erythema Multiforme Treated with Dapsone
Senay Agirgol1, Kamer Faruk Coşkun, Ceyda Caytemel
1Senay Agirgol, Haseki Training and Research Hospital, Millet Caddesi Aksaray, Istanbul, Turkey; senayagirgol@hotmail.com.
Acta Dermatovenerologica Croatica : ADC
|July 14, 2025
Summary
Persistent erythema multiforme (PEM) is a rare, continuous inflammatory condition. This case report suggests that 50 mg of dapsone may effectively control PEM, contributing valuable treatment insights.
Area of Science:
- Dermatology
- Clinical Medicine
Background:
- Erythema multiforme presents in classic, recurrent, or persistent forms.
- Persistent erythema multiforme (PEM) is a rare variant with a continuous course and potential for inflammatory presentations.
- PEM is characterized by uninterrupted target-like lesions, with etiology and treatment data primarily from case reports.
Observation:
- A 37-year-old male presented with palmar lesions and severe oral bullae and ulcers.
- The patient's condition was managed with systemic steroids and dapsone.
- The case highlights the rarity of PEM and the need for case-based evidence.
Findings:
- The presented case of persistent erythema multiforme was treated with 50 mg dapsone.
- Dapsone demonstrated efficacy in controlling the inflammatory clinical manifestations of PEM.
- This case contributes to the limited literature on PEM treatment.
Implications:
- Reporting this case provides evidence for dapsone as a potential treatment for persistent erythema multiforme.
- The findings may guide future clinical management strategies for this rare condition.
- Further research into the etiology and optimal treatment of PEM is warranted.
