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A Case of Persistent Erythema Multiforme Treated with Dapsone
Senay Agirgol1, Kamer Faruk Coşkun, Ceyda Caytemel
1Senay Agirgol, Haseki Training and Research Hospital, Millet Caddesi Aksaray, Istanbul, Turkey; senayagirgol@hotmail.com.
Abstract:
Erythema multiforme is a clinical entity that presents in three different clinical forms, namely classic, recurrent, or persistent. Persistent erythema multiforme (PEM) is a rare variant that may be localized in different regions compared with the classical erythema multiforme, has a continuous course, and can present in inflammatory clinical forms. PEM was defined as the uninterrupted persistence of typical or atypical target-like lesions. Data about its etiology and treatment is obtained from case reports. Herein, we present the case of a 37-year-old male patient who presented to our outpatient clinic with palmar lesions and with the presence severe oral bullae and ulcers treated with systemic steroids and dapsone. Due to the rarity of the disease, reporting this case is expected contribute to the literature and provide evidence that 50 mg dapsone treatment may be used to control PEM.
Insights
Persistent erythema multiforme (PEM) is a rare, continuous inflammatory condition. This case report suggests that 50 mg of dapsone may effectively control PEM, contributing valuable treatment insights.
Area of Science:
- Dermatology
- Clinical Medicine
Background:
- Erythema multiforme presents in classic, recurrent, or persistent forms.
- Persistent erythema multiforme (PEM) is a rare variant with a continuous course and potential for inflammatory presentations.
- PEM is characterized by uninterrupted target-like lesions, with etiology and treatment data primarily from case reports.
Observation:
- A 37-year-old male presented with palmar lesions and severe oral bullae and ulcers.
- The patient's condition was managed with systemic steroids and dapsone.
- The case highlights the rarity of PEM and the need for case-based evidence.
Findings:
- The presented case of persistent erythema multiforme was treated with 50 mg dapsone.
- Dapsone demonstrated efficacy in controlling the inflammatory clinical manifestations of PEM.
- This case contributes to the limited literature on PEM treatment.
Implications:
- Reporting this case provides evidence for dapsone as a potential treatment for persistent erythema multiforme.
- The findings may guide future clinical management strategies for this rare condition.
- Further research into the etiology and optimal treatment of PEM is warranted.
