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Updated: Sep 15, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Artificial Intelligence and Machine Learning to Improve Evidence Synthesis Production Efficiency: An Observational
Christopher James Rose1,2, Jose Francisco Meneses-Echavez1,3, Ashley Elizabeth Muller1,4
1Reviews and Health Technology Assessments, Division of Health Services Norwegian Institute of Public Health Oslo Norway.
Artificial intelligence and machine learning (AI/ML) tools did not significantly impact the time or resources needed for evidence syntheses in this study. Further research is needed to determine the true efficiency gains of AI/ML in systematic reviews.
Area of Science:
- Health Services Research
- Information Science
Background:
- Evidence syntheses are vital but time-consuming and resource-intensive.
- Artificial intelligence and machine learning (AI/ML) offer potential efficiency improvements in review processes.
- The impact of AI/ML on the entirety of evidence synthesis production remains largely unknown.
Purpose of the Study:
- To analyze the impact of AI/ML tools on resource use and completion time for evidence syntheses.
- To compare reviews using AI/ML with those that did not, based on internal recommendations.
Main Methods:
- Prespecified analyses of healthcare- or welfare-related reviews commissioned between August 2020 and January 2023.
- Compared reviews using AI/ML tools (ranking, classification, clustering, bibliometrics) versus those without.
- Accounted for nonrandomized assignment and censored outcomes; researchers and statisticians were blinded.
Main Results:
- AI/ML tools were used in 69% of the 39 reviewed studies.
- Reviews using AI/ML reportedly used more resources (667 vs. 291 person-hours) and were completed slightly faster (27.6 vs. 28.2 weeks).
- These differences in resource use and completion time were not statistically significant.
Conclusions:
- The association between AI/ML use and efficiency in evidence synthesis remains uncertain.
- Larger, multicenter studies or meta-analyses may be required to definitively assess the benefits of AI/ML tools.
- Further investigation is needed to determine if AI/ML tools can meaningfully reduce the time and resources required for evidence synthesis production.
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