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A Strategic Antimetastatic Solution for Bone-Targeting Prostate Cancer via Nanoengineered Niclosamide
Sanoj Rejinold N1, Geun-Woo Jin2, Jin-Ho Choy1,3
1Intelligent Nanohybrid Materials Laboratory (INML), Department of Chemistry, College of Science and Technology, Dankook University, Cheonan 31116, Republic of Korea.
Abstract:
Prostate cancer is the second leading cause of cancer-related deaths in men worldwide, with bone metastasis being the predominant driver of morbidity and mortality in advanced stages. This underscores the urgent need for innovative therapeutic strategies to address skeletal metastasis and improve patient outcomes. Niclosamide, a long-standing anthelminthic drug, has emerged as a promising multipathway modulator against cancer hallmarks. Here, we propose a nanotechnology-enabled repurposing of niclosamide, hypothesizing that its formulation into smart, targeted nanohybrids could not only suppress prostate tumor growth but also inhibit its dissemination to the skeletal system. We discuss the molecular rationale, design considerations, and translational outlook for nanoengineered niclosamide in the context of metastatic prostate cancer.
Insights
Repurposing the drug niclosamide using nanotechnology may offer a new strategy to combat advanced prostate cancer and prevent its spread to bones. This approach targets cancer hallmarks to improve patient outcomes.
Area of Science:
- Oncology
- Nanotechnology
- Drug Repurposing
Background:
- Prostate cancer is a leading cause of male cancer deaths globally.
- Skeletal metastasis significantly drives mortality in advanced prostate cancer.
- Innovative therapies are crucial for managing bone metastasis and improving patient survival.
Purpose of the Study:
- To explore the potential of nanotechnology-enabled niclosamide for treating metastatic prostate cancer.
- To investigate the efficacy of niclosamide nanohybrids in suppressing tumor growth and bone dissemination.
- To provide a molecular rationale and design considerations for nanoengineered niclosamide.
Main Methods:
- Formulating niclosamide into smart, targeted nanohybrids.
- Evaluating the anti-cancer properties of nanoengineered niclosamide.
- Assessing the inhibition of prostate tumor growth and skeletal metastasis.
Main Results:
- Niclosamide demonstrates multipathway modulation against cancer hallmarks.
- Nanotechnology-based formulation enhances niclosamide's therapeutic potential.
- Targeted nanohybrids show promise in suppressing tumor growth and metastasis.
Conclusions:
- Nanoengineered niclosamide presents a promising therapeutic strategy for metastatic prostate cancer.
- This approach could potentially inhibit skeletal metastasis and improve patient outcomes.
- Further research and translational studies are warranted for clinical application.
