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Related Experiment Videos

Frequency of obsessive-compulsive symptoms (OCS) in medical students and their possible association with a history of

Juan Manuel Duarte1, Osvaldo Juan Ponzo2, Marcelo Fabián Garro3

  • 1Médico Neurólogo. División Neuropsicofarmacología, Departamento de Salud Mental. Hospital de Clínicas "José de San Martín". Universidad de Buenos Aires. Instituto de Neurociencias, Hospital Alemán, Buenos Aires. . jduarte@fmed.uba.ar.

Vertex (Buenos Aires, Argentina)
|July 14, 2025
PubMed
Summary

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This summary is machine-generated.

This study found that nearly 27% of medical students experienced obsessive-compulsive symptoms, with a notable link to recurrent adult strep throat infections. Further research is needed to explore immune-mediated OCD connections.

Area of Science:

  • Neuroscience and Immunology
  • Psychiatry
  • Epidemiology

Context:

  • Obsessive-compulsive disorder (OCD) affects 2.5% of the general population, with unknown etiology.
  • Previous research has primarily focused on childhood-onset OCD, particularly PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections).
  • The role of recurrent infections in adult OCD remains under-explored.

Purpose:

  • To determine the frequency of obsessive-compulsive symptoms (OCS) among second-year medical students at the University of Buenos Aires.
  • To investigate the potential association between OCS and a history of recurrent pharyngitis.
  • To explore the link between OCS and recurrent streptococcal infections in adulthood.

Summary:

  • A cross-sectional study of 494 medical students revealed a 26.92% prevalence of OCS.
Keywords:
obsessive-compulsive disorderstreptococcal infectionpharyngitismedical studentscross-sectional studies

Related Experiment Videos

  • Bivariate analysis showed associations between OCS and gender, childhood recurrent sore throat, and adult recurrent sore throat.
  • Multivariate analysis confirmed a significant association between OCS and recurrent adult sore throat, suggesting a potential immune-mediated pathway.

    • Impact:

    • Challenges the notion that PANDAS is exclusively a childhood disorder.
    • Suggests a potential link between adult-onset OCD and recurrent streptococcal infections, possibly immune-mediated.
    • Highlights the need for further research into specific antibodies and therapeutic interventions for OCD.