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Updated: Sep 8, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Choline-geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs
Marta Costa Verdugo1,2,3, Giulia Sierri3, Laura Hernandez-Fernandez1,2
1Donostia International Physics Center (DIPC), Donostia-San Sebastián, Euskadi, Spain. lsalassa@dipc.org.
Abstract:
The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(II) and Pt(IV) complexes was investigated. All complexes exhibited appreciable solubility in CAGE ILs, with Pt(II) complexes 2 and 4 undergoing immediate ligand substitution. In contrast, the hydrophobic derivative 3 demonstrated remarkable stability for up to 48 hours. 19F-1H HOESY NMR analysis revealed that 3 localized within the hydrophobic regions of CAGE 1 : 2 (choline:geranate). When tested in U87-MG glioblastoma cells, CAGE ILs enhanced the anticancer activity of the Pt complexes. Notably, complex 3 exhibited a significant increase in cytotoxicity, nearly completely reducing cell viability when formulated with CAGE IL.
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