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Updated: Sep 15, 2025
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Comparative evaluation of amniotic membrane and titanium-prepared platelet-rich fibrin in root coverage: A randomized
Devadharshini Chandrasekar1, Burnice Nalina Kumari Chellathurai1, Jaideep Mahendra1
1Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research , Chennai, Tamil Nadu, India.
Background:
Gingival recession, particularly Cairo's RT1 and RT2 defects, presents a persistent challenge in periodontal therapy. The comparative effectiveness of soft tissue regenerative materials specifically Amniotic Membrane and Titanium-Prepared Platelet-Rich Fibrin (T-PRF) in the microsurgical management of these defects using the coronally advanced flap (CAF) technique remains inadequately explored.
Aim:
To clinically evaluate and compare the efficacy of Amniotic Membrane and T-PRF in the treatment of isolated Cairo's RT1 and RT2 gingival recession defects using the CAF technique.
Materials And Methods:
A randomized, split-mouth clinical trial was conducted involving 20 patients with bilateral Cairo's RT1 and RT2 recession defects. A total of 46 sites were treated-23 with Amniotic Membrane (Group A) and 23 with T-PRF (Group B), using the CAF technique under surgical magnification. Clinical parameters assessed at baseline, 90 days, and 180 days included recession depth and width, probing pocket depth, clinical attachment level, width of keratinized gingiva, gingival thickness, and mean root coverage.
Results:
Both treatment modalities resulted in significant clinical improvements over time. However, Group B (T-PRF) demonstrated statistically superior outcomes in recession depth reduction, clinical attachment level gain, increased keratinized tissue width, greater gingival thickness, and higher mean root coverage compared to Group A (Amniotic Membrane).
Conclusion:
T-PRF exhibited enhanced regenerative potential over Amniotic Membrane in the management of isolated Cairo's RT1 and RT2 recession defects when used in conjunction with the CAF technique. These findings support the clinical utility of T-PRF as an effective soft tissue grafting material in periodontal plastic surgery.
