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Updated: Mar 31, 2026

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
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Periodontal regeneration with Bio-Oss for intrabony defect management: A case report
K Lakshmi Priya1, Uma Subbiah1, Sarumathi D1
1Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, Tamil Nadu, India.
Bioinformation
|March 30, 2026
Summary
This study shows that using demineralized bovine bone mineral and a GTR membrane effectively regenerated bone in a patient with chronic periodontitis, reducing pocket depth and improving bone fill.
Area of Science:
- Periodontal regeneration
- Biomaterials in dentistry
- Bone grafting
Background:
- Periodontitis involves the loss of tooth-supporting structures.
- Regenerative periodontal therapy aims to restore lost tissues.
- Intrabony defects are a common challenge in periodontitis management.
Purpose of the Study:
- To evaluate the efficacy of xenograft-based regenerative therapy for an intrabony defect.
- To assess the outcomes of using demineralized bovine bone mineral and a GTR membrane.
- To demonstrate successful periodontal regeneration in a chronic periodontitis case.
Main Methods:
- Treatment of an intrabony defect in teeth 16 and 17 using demineralized bovine bone mineral (Bio-Oss®) and a guided tissue regeneration (GTR) membrane (Bio-Gide®).
- Initial non-surgical periodontal therapy followed by open flap debridement and regenerative treatment.
- Clinical and radiographic assessments at one, three, and six months post-treatment.
Main Results:
- Significant reduction in periodontal pocket depth observed.
- Radiographic evidence of substantial bone fill within the defect area.
- Successful regeneration of periodontal supporting structures indicated.
Conclusions:
- Xenograft-based regenerative therapy, utilizing demineralized bovine bone mineral and a GTR membrane, is effective for localized chronic periodontitis.
- This approach successfully treated an intrabony defect, leading to periodontal regeneration.
- The findings support the use of Bio-Oss® and Bio-Gide® for periodontal bone regeneration.

