Recent Developments in Vesicular Nanocarriers for Targeted Drug Delivery in Breast Cancer

Area of Science:

• Oncology
• Nanotechnology
• Pharmacology

Background:

• Breast cancer heterogeneity complicates treatment response and tumor progression.
• Innovative therapeutic strategies are crucial for improving patient outcomes.
• Vesicular nanocarriers show potential for advanced breast cancer therapy.

Purpose of the Study:

• To review the application of various vesicular nanocarriers in enhancing breast cancer treatment efficacy.
• To analyze recent advancements in functionalization and application of these nanocarriers.
• To assess passive and active targeting strategies for improved tumor drug accumulation.

Main Methods:

• Exploration of vesicular nanocarriers: liposomes, niosomes, ethosomes, polymerosomes, phytosomes, and transferosomes.
• Analysis of nanocarrier functionalization for improved pharmacokinetics and solubility.
• Assessment of passive (EPR effect) and active targeting (surface modifications) strategies.

Main Results:

• Vesicular nanocarriers enhance drug bioavailability and solubility.
• Targeted delivery via nanocarriers reduces systemic toxicity.
• Both passive and active targeting increase drug accumulation in tumors.

Conclusions:

• Vesicular nanocarriers represent a significant advancement in breast cancer therapy.
• These systems enable precise drug delivery, minimizing off-target effects.
• Integration of nanocarriers offers potential for personalized and effective breast cancer treatment.