Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hypophosphatasia and collagen VI-related muscular dystrophy presenting with gait disturbance and recurrent fractures.

JCEM case reports·2026

Same author

Experience-based co-design to refine a remote parent-mediated intervention program for preterm infants after NICU discharge: a qualitative study.

BMC pediatrics·2026

Same author

Magnetic Resonance Neurography in Spontaneous Radial Neuropathy: An Unexpectedly High Rate of Nerve Constriction.

Muscle & nerve·2026

Same author

Genetic testing and genetic findings in Korean children with cerebral palsy.

Developmental medicine and child neurology·2026

Same author

HLA-A*2402 May Be Associated With Antiseizure Medication-Induced Severe Mucocutaneous Adverse Events in Korean Population.

Journal of clinical neurology (Seoul, Korea)·2026

Same author

Feasibility and Preliminary Effectiveness of a Mobile App-Based Personalized Exercise Program in Older Patients With Chronic Knee Osteoarthritis: Pilot Randomized Controlled Trial.

JMIR mHealth and uHealth·2025

Search research articles

Related Experiment Video

Updated: Sep 15, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy.

Yu Jin Im^1,2, Yumi Choe¹, Jiwon Lee^2,3

¹Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Seoul, Republic of Korea.

|July 17, 2025

Summary

Quantitative muscle ultrasound (QMUS) can track Duchenne muscular dystrophy (DMD) progression. Composite QMUS scores correlate with functional capacity, offering a non-invasive biomarker for disease monitoring.

Keywords:

Duchenne muscular dystrophy functional capacity grayscale level analysis muscle ultrasound

More Related Videos

A Novel Application of Musculoskeletal Ultrasound Imaging

A Novel Application of Musculoskeletal Ultrasound Imaging

Published on: September 17, 2013

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Related Experiment Videos

Last Updated: Sep 15, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

A Novel Application of Musculoskeletal Ultrasound Imaging

A Novel Application of Musculoskeletal Ultrasound Imaging

Published on: September 17, 2013

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease

Published on: December 18, 2016

Area of Science:

Neurology
Biomarkers
Medical Imaging

Background:

Duchenne muscular dystrophy (DMD) is a progressive genetic disorder characterized by muscle degeneration.
Non-invasive biomarkers are crucial for monitoring disease progression and treatment efficacy in DMD.
Quantitative muscle ultrasound (QMUS) has emerged as a promising tool for assessing muscle health.

Purpose of the Study:

To evaluate the correlation between QMUS parameters in various muscles and established functional capacity assessments in patients with DMD.
To compare the utility of composite QMUS scores versus single-muscle QMUS analyses for tracking DMD progression.

Main Methods:

Analysis of baseline data from 23 patients with DMD (aged 5-18 years).
High-resolution ultrasound scans assessed muscle echogenicity (mean grayscale values - MGV) in multiple muscle groups.
Functional capacity was evaluated using the 6-minute walk test (6MWT), North Star Ambulatory Assessment (NSAA), Performance of Upper Limb (PUL) module, timed function tests, and strength tests.

Main Results:

Composite QMUS scores for upper and lower limbs showed moderate to strong negative correlations with 6MWT and NSAA scores.
Composite QMUS scores demonstrated strong positive correlations with functional timed tests (e.g., rise-from-floor, stair climb).
MGV of the flexor carpi radialis correlated with upper limb function (PUL scores), but QMUS did not correlate significantly with muscle strength tests.

Conclusions:

QMUS provides a non-invasive method for assessing muscle integrity in DMD.
Composite QMUS scores effectively correlate with functional capacity and can serve as a comprehensive biomarker for DMD progression.