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Published on: July 12, 2024
Development and Optimization of a Cilostazol-Loaded Nanomicelle Transdermal Patch for Hypertension Management
Vaishali Thakkar1, Prima Patel1, Khyati Parekh1
1Department of Pharmaceutics, Anand Pharmacy College, Gujarat Technological University, Ahmedabad, Gujarat.
Background:
This study aimed to develop and optimize a cilostazol-loaded nanomicelle transdermal patch to enhance solubility, stability, and controlled drug release.
Objective:
To improve cilostazol bioavailability by formulating a stable, nanomicelle-loaded transdermal patch.
Methods:
Nanomicelles were prepared using the thin-film hydration method with Soluplus and Poloxamer 188 as the polymer and surfactant. The transdermal patch was fabricated using the solvent casting method and evaluated for tensile strength, folding endurance, and in vitro drug diffusion.
Results:
The optimized formulation showed 97.71% entrapment efficiency, 48.86% drug loading, a particle size of 129.07 nm, and a zeta potential of -21.5 mV. The patch exhibited a tensile strength of 141.83 MPa, folding endurance of over 300 folds, and sustained in vitro drug diffusion.
Conclusion:
The developed transdermal patch offers a promising strategy to enhance cilostazol bioavailability by bypassing first-pass metabolism, promoting better penetration, and ensuring improved patient compliance.
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