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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Techniques to Induce and Quantify Cellular Senescence
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Gene therapy strategies for aging intervention.

Yaobin Jing1, Jie Ren2,3,4,5,6,7, Jing Qu8,9,2,3

  • 1International Center for Aging and Cancer, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, Hainan, China.

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Gene therapy offers a promising approach to combat aging and its associated diseases. This review explores how gene interventions can enhance healthspan and promote longevity by targeting aging mechanisms.

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Area of Science:

  • Biomedical Science
  • Gerontology
  • Molecular Biology

Background:

  • Aging is a natural process involving gradual decline in organ function, increasing chronic disease risk.
  • Interventions to slow aging could reduce disease burden and promote healthy longevity.
  • Gene therapy presents a powerful clinical tool to address aging's molecular roots.

Purpose of the Study:

  • To systematically review gene therapy strategies for aging intervention.
  • To explore gene therapy's potential in enhancing genomic stability, metabolic health, immune function, and cellular rejuvenation.
  • To provide insights for future research and clinical translation of gene therapy for aging.

Main Methods:

  • Literature review of gene therapy approaches targeting aging.
  • Focus on strategies for genomic/epigenetic stability, metabolic homeostasis, immune modulation, and senescent cell clearance.
  • Analysis of current research and future translational potential.

Main Results:

  • Gene therapy can target key aging hallmarks, including genomic instability, epigenetic alterations, metabolic dysfunction, immune senescence, and cellular senescence.
  • Specific strategies show promise in preclinical models for mitigating age-related decline.
  • The review synthesizes diverse gene therapy applications for aging intervention.

Conclusions:

  • Gene therapy holds significant potential to delay aging and improve healthspan.
  • Targeting molecular aging pathways via gene editing and delivery systems is a viable strategy.
  • Further research and clinical translation are crucial for realizing gene therapy's benefits in aging populations.