Gene therapy strategies for aging intervention

Area of Science:

• Biomedical Science
• Gerontology
• Molecular Biology

Background:

• Aging is a natural process involving gradual decline in organ function, increasing chronic disease risk.
• Interventions to slow aging could reduce disease burden and promote healthy longevity.
• Gene therapy presents a powerful clinical tool to address aging's molecular roots.

Purpose of the Study:

• To systematically review gene therapy strategies for aging intervention.
• To explore gene therapy's potential in enhancing genomic stability, metabolic health, immune function, and cellular rejuvenation.
• To provide insights for future research and clinical translation of gene therapy for aging.

Main Methods:

• Literature review of gene therapy approaches targeting aging.
• Focus on strategies for genomic/epigenetic stability, metabolic homeostasis, immune modulation, and senescent cell clearance.
• Analysis of current research and future translational potential.

Main Results:

• Gene therapy can target key aging hallmarks, including genomic instability, epigenetic alterations, metabolic dysfunction, immune senescence, and cellular senescence.
• Specific strategies show promise in preclinical models for mitigating age-related decline.
• The review synthesizes diverse gene therapy applications for aging intervention.

Conclusions:

• Gene therapy holds significant potential to delay aging and improve healthspan.
• Targeting molecular aging pathways via gene editing and delivery systems is a viable strategy.
• Further research and clinical translation are crucial for realizing gene therapy's benefits in aging populations.