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Updated: Sep 15, 2025
Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
Published on: January 11, 2020
3D-printed phantoms for measuring lateral resolution and contrast performance of ophthalmic adaptive optics imaging
Anant Agrawal1, Ian Rosenthal1,2, Declan Fitzgerald1,2
1Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA.
Abstract:
Adaptive optics (AO) imaging of the human retina is an emerging clinical technique that confers the highest possible spatial resolution of this tissue in vivo. To support consistent imaging performance across time and devices, we have designed and fabricated a robust and user-friendly phantom that can determine lateral resolution and contrast with 3D-printed microstructures approximating cone photoreceptors. We have carefully characterized multiple copies of this phantom via microscopic imaging and metrology, and we also demonstrated the phantom's utility with two different AO imaging modalities. Our results indicate that this phantom, with its associated ground truth data, can be a very effective qualitative and quantitative evaluation tool for ophthalmic AO devices.
