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Updated: Sep 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Transition-metal-catalyzed alkene-relayed intermolecular C-H activation
Qiongqiong Zhu1, Ming-Shun Mei1, Xiang Zuo1
1School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092, China. zhangyanghui@tongji.edu.cn.
Abstract:
Alkene-relayed C-H activation constitutes a novel strategy for selective C-H functionalization. In this context, intermolecular reactions that incorporate alkenes into the final products are of significant interest. During these transformations, alkenes not only act as a relay for C-H activation but also serve as carbon synthons, becoming integral components of the product architecture. This dual role enhances their utility in transition-metal-catalyzed C-H activation, broadening the scope of synthetic applications. This review systematically summarizes such alkene-relayed C-H functionalization reactions. The discussed reactions are categorized based on alkene type, metal catalyst, and transformation class, with detailed mechanistic insights provided for representative examples. Additionally, the review highlights current challenges and future prospects for research in this evolving field.
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