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Intraoperative Spectrally Encoded Coherence Tomography and Reflectometry (iSECTR) for Ophthalmic Surgical Guidance.

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We optimized an intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) system for ophthalmic surgery. This enhanced system offers stable, high-quality imaging and improved ergonomics, paving the way for clinical translation.

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Area of Science:

  • Ophthalmic surgery
  • Medical imaging
  • Optical coherence tomography

Background:

  • Intraoperative optical coherence tomography (iOCT) is crucial for ophthalmic surgery.
  • Previous iOCT systems faced barriers to clinical translation due to stability and ergonomic issues.

Purpose of the Study:

  • To present an optimized intraoperative spectrally encoded coherence tomography and reflectometry (iSECTR) system.
  • To improve system stability, optical throughput, and reduce artifacts for clinical use.

Main Methods:

  • Integrated an iSECTR scan-head with a Zeiss OPMI VISU 200 ophthalmic surgical microscope.
  • Designed a compact scan-head with motorized focus adjustment.
  • Demonstrated imaging performance in vivo (human eyes) and ex vivo (porcine eyes).

Main Results:

  • Achieved a compact scan-head footprint (19.67 × 30.2 cm) with minimal height increase (6.06 cm).
  • Motorized focusing accommodated ±10 D of focal shift.
  • Resolved clinically relevant retinal and corneal features, and tissue deformation during simulated surgery.

Conclusions:

  • The optimized iSECTR scan-head demonstrates robust performance suitable for clinical translation.
  • Improved spectrally encoded reflectometry (SER) imaging enables reproducible anterior and posterior eye imaging.
  • Independent focus adjustment enhances clinical ergonomics and supports future applications like automated tracking and 4D visualization.